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Seroprevalence of hepatitis A virus among newly admitted medical students in Dhamar, Yemen Featured

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Original Research:

Abdulsalam  M. Al-Mekdad, Mohammed Q. Salah, Mohammed H. Al-dholae, Khalil I. Al-Shakhab, Omar S. Belfaqih, Ahmed N. Alareeq


Background: Health science students are at increased risk of hepatitis A virus (HAV) infection even under accidental infection. The occurrence of HAV infection is routinely diagnosed serologically by detection of specific anti-HAV in a serum sample. Hepatitis A infections in developing countries are substantially underestimated because HAV infections in young children are mostly asymptomatic and therefore unrecognized

Aim: The study aims to determine the seroprevalence of HAV-IgG antibody among medical students to assess the prevalence of acquired immunity to HAV infection.

Methods: A cross‑sectional study was conducted among 1styear medical students. Information was collected by pretested structured questionnaire. The anti-HAV-IgG antibodies was assessed, serological results were then added to questionnaire chart of all participants.

Results: The seropositivity of HAV (anti-HAV IgG antibodies) in newly admitted students was 88 (94.6%). Medical student's residence, gender, the household size, the source of drinking water, availability of toilet and individual or family history of hepatitis did not significantly influence the anti-HAV (IgG) positivity in studied subjects (P > 0.05).

Conclusion: Our results indicate that majority of the medical students were seropositive for IgG anti-HAV and had acquired immunity to HAV infection and hence at a decreased risk of developing HAV infection as a result of occupational exposure.


Keywords: Seroprevalence, hepatitis A virus, Anti-HAV IgG, Medical students, Yemen.


Abdulsalam  M. Al-Mekdad1*, Mohammed Q. Salah1, Mohammed H. Al-dholae1, Khalil I. Al-Shakhab1, Omar S. Belfaqih1, Ahmed N. Alareeq2

1Department of Medicine Department, Faculty of Medicine, Thamar University, Dhamar, Yemen
2Department of Medical Laboratory, Al Wahda Teaching Hospital, Thamar University, Dhamar, Yemen
*For Correspondence:
Abdulsalam  M. AL-Mekdad
Faculty of Medicine, Thamar University, Dhamar, Yemen
Tel: +967 771 155 065
Email: This email address is being protected from spambots. You need JavaScript enabled to view it. 


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